This will be a theoretical course to illustrate the drug discovery process from target to lead with special focus on DivIDe. It will also provide insights into the main disciplines for lead structure development. ESRs will learn the development of small molecules and biochemical and cellular assays, high throughput screening, cellular biology in early drug discovery, medicinal chemistry, rational drug design, and pharmacological profiling. ESRs will familiarise with IP strategies for the protection of novel chemical entities.